Thursday, May 14, 2020
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Nvidia launches Clara Guardian, an edge AI system that uses sensors for contactless patient monitoring to limit infectious disease spread, in 50 hospitals (Khari Johnson/VentureBeat)
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Immunai wants to map the entire immune system and raised $20 million in seed funding to do it
For the past two years the founding team of Immunai had been working stealthily to develop a new technology to map the immune system of any patient.
Founded by Noam Solomon, a Harvard and MIT-educated postdoctoral researcher, and former Palantir engineer, Luis Voloch, Immunai was born from the two men’s interest in computational biology and systems engineering. When the two were introduced to Ansuman Satpathy, a professor of cancer immunology at Stanford University, and Danny Wells, who works as a data scientist at the Parker Institute for Cancer Immunotherapy the path forward for the company became clear.
“Together we said we bring the understanding of all the technology and machine learning that needs to be brought into the work and Ansu and Danny bring the single-cell biology,” said Solomon.
Now as the company unveils itself and the $20 million in financing it has received from investors including Viola Ventures and TLV Partners, it’s going to be making a hiring push and expanding its already robust research and development activities.
Immunai already boasts clinical partnerships with over ten medical centers and commercial partnerships with several biopharma companies, according to the company. And the team has already published peer-reviewed work on the origin of tumor-fighting T cells following PD-1 blockade, Immunai said.
“We are implementing a complicated engineering pipeline. We wanted to scale to hundreds of patients and thousands of samples,” said Wells. “Right now, in the world of cancer therapy, there are new drugs coming on the market that are called checkpoint inhibitors. [We’re] trying to understand how these molecules are working and find new combinations and new targets. We need to see the immune system in full granularity.”
That’s what Immunai’s combination of hardware and software allows researchers to do, said Wells. “It’s a vertically integrated platform for single cell profiling,” he said. “We go even further to figure out what the biology is there and figure that out in a new combination design for the trial.”
Cell therapies and cancer immunotherapies are changing the practice of medicine and offering new treatments for conditions, but given how complex the immune system is, the developers of those therapies have few insights into how their treatments will effect the immune system. Given the diversity of individual patients variations in products can significantly change the way a patient will respond to the treatment, the company said.
Photo: Andrew Brookes/Getty Images
Immunai has the potential to change the way these treatments are developed by using single-cell technologies to profile cells by generating over a terabyte of data from an individual blood sample. The company’s proprietary database and machine learnings tools map incoming data to different cell types and create profiles of immune responses based on differentiated elements. Finally, the database of immune profiles supports the disvovery of biomarkers that can then be monitored for potential changes.
“Our mission is to map the immune system with neural networks and transfer learning techniques informed by deep immunology knowledge,” said Voloch, in a statement. “We developed the tools and knowhow to help every immuno-oncology and cell therapy researcher excel at their job. This helps increase the speed in which drugs are developed and brought to market by elucidating their mechanisms of action and resistance.”
Pharmaceutical companies are already aware of the transformational potential of the technology, according to Solomon. The company is already in the process of finalizing a seven-figure contract from a Fortune 100 company, according to Solomon.
One of the company’s earliest research coups was using research to show the way that immune systems function when anti-PD1 molecules are introduced. Typically the presence of PD-1 means that t-cell production is being suppressed. What the research from ImmuneAI revealed was that the response wasn’t happening with T-cells within the tumor. There were new t-cells that were migrating to the tumor to fight it off, according to Wells.
“This whole approach that we have around looking at all of these indications — we believe that the right way and most powerful way to study these diseases is to look at the immune system from the top down,” said Voloch, in an interview. “Looking at all of these different scenarios. From the top, you see these patterns than wouldn’t be available otherwise.”
Microsoft opens up its threat intelligence data, including file hash indicators used in email scams, to wider security community via GitHub during the pandemic (Shannon Vavra/CyberScoop)
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As pandemic-related budget cuts come to call centers, organizations turn to chatbots like IBM's Watson to filter calls, reducing the need for human operators (Karen Hao/MIT Technology Review)
As pandemic-related budget cuts come to call centers, organizations turn to chatbots like IBM's Watson to filter calls, reducing the need for human operators — Covid-19 is accelerating job losses in an industry that was already automating work at a rapid pace. — Brian Pokorny had heard of AI systems for call centers before.
Wednesday, May 13, 2020
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OnePlus 8 series along with the 5G variant will go on sale in India on May 29
The OnePlus 8 and 8 Pro finally have a release date in India. Customers will be able to get their hands on the devices starting May 29. The smartphones are up for pre-order on Amazon.in. OnePlus has also said that the 5G variant of the OnePlus 8 Series will be available in India from May 29. However, OnePlus has also said that in a special early access sale, the OnePlus 8 5G will be made available in limited quantity starting at 2 pm on Amazon.in on 18th May.
OnePlus 8 series 5G launch offersAlong with sales going live, OnePlus has also introduced several launch offers that will go live on purchase of the OnePlus 8 Series 5G starting 29 May. The offers are as follows.
Rs 3000 Instant Discount on OnePlus 8 Pro 5G and Rs 2000 Instant Discount on OnePlus 8 5G on purchase with SBI Credit Cards. Up to 12 months no-cost EMI across oneplus.in and Amazon.in on purchase using popular bank debit and credit cards. Additionally, users can avail up to 12 months of no-cost EMI at no extra cost across all online and offline channels on purchase with SBI Credit Cards. With Bajaj Finance, users can now purchase the devices at one-third of the total value, while paying the remaining amount at low monthly instalments over the course of 12 months. Benefits worth Rs 6000 including Rs 150 off on 40 prepaid recharges of Rs 349 with Jio Exclusive OnePlus 8 Series 5G Pop Up Bundle sale for Red Cable Club members on 28 May 2020The Limited Edition pop-up bundle, available for both OnePlus 8 5G and OnePlus 8 Pro 5G will include the OnePlus 8 Series device along with a pair of Bullets Wireless Z (Black) earphones, a Cyan Bumper Case and a Karbon Bumper Case at just Rs 1000 above the retail price of the OnePlus 8 Series device.
The pop-up bundle will open up for an exclusive sale for Red Cable Club members on 28 May 2020, starting at Rs Rs 45,999. The Pop Up Bundle is a limited series that will be available for purchase through invite codes only. Those interested can stay tuned on the Red Cable Club membership page for more information on invite codes. Later, the Limited Edition pop up bundle will be available on select channels.
OnePlus 8, OnePlus 8 Pro India PriceThe OnePlus 8 is priced at Rs INR 41,999 for the 6GB RAM + 128GB storage variant and Rs 44,999 for the 8GBRAM and 128GB storage variant. Finally, the 12GB RAM + 128GB storage variant is priced at Rs 49,999. The OnePlus 8 Pro, on the other hand, starts at Rs 54,999 for the 8GB RAM + 128GB storage variant and the 12GB RAM + 256GB storage variant is priced at Rs 59,999.
In other OnePlus news, OnePlus India General Manager, Vikas Agarwal said the company has started manufacturing the smartphones (OnePlus 8 series) in India and they will go on sale in the country soon. OnePlus relies on the Oppo factory in Greater Noida in Uttar Pradesh for manufacturing, and the company resumed operations earlier last week. Mr Agarwal also said the phones will be made available for sale from May end. You can read more about Made in India OnePlus devices here.
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